Breathing with Phox2b
نویسندگان
چکیده
منابع مشابه
Breathing with phox2b.
In the last few years, elucidation of the architecture of breathing control centres has reached the cellular level. This has been facilitated by increasing knowledge of the molecular signatures of various classes of hindbrain neurons. Here, we review the advances achieved by studying the homeodomain factor Phox2b, a transcriptional determinant of neuronal identity in the central and peripheral ...
متن کاملBreathing without CO(2) chemosensitivity in conditional Phox2b mutants.
Breathing is a spontaneous, rhythmic motor behavior critical for maintaining O(2), CO(2), and pH homeostasis. In mammals, it is generated by a neuronal network in the lower brainstem, the respiratory rhythm generator (Feldman et al., 2003). A century-old tenet in respiratory physiology posits that the respiratory chemoreflex, the stimulation of breathing by an increase in partial pressure of CO...
متن کاملSleep-disordered breathing in newborn mice heterozygous for the transcription factor Phox2b.
RATIONALE Central congenital hypoventilation syndrome (CCHS) is a rare autosomal dominant syndrome present from birth, and characterized by depressed ventilation during sleep. Heterozygous mutations of the homeobox gene Phox2b were recently found in a very high proportion of patients. OBJECTIVES To determine whether newborn mice with heterozygous targeted deletion of the transcription factor ...
متن کاملPhox2b and motoneuronal differentiation
The specification of neuronal subtype identity in the developing central nervous system (CNS) appears to be controlled by the interplay between inductive signals secreted by embryonic signaling centers and the transcription factors that transmit this information onto the transcriptional apparatus (Lumsden and Krumlauf, 1996; Edlund and Jessell, 1999). A large number of different transcription f...
متن کاملPhotostimulation of retrotrapezoid nucleus phox2b-expressing neurons in vivo produces long-lasting activation of breathing in rats.
The retrotrapezoid "nucleus" (RTN), located in the rostral ventrolateral medullary reticular formation, contains a bilateral cluster of approximately 1000 glutamatergic noncatecholaminergic Phox2b-expressing propriobulbar neurons that are activated by CO(2) in vivo and by acidification in vitro. These cells are thought to function as central respiratory chemoreceptors, but this theory still lac...
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ژورنال
عنوان ژورنال: Philosophical Transactions of the Royal Society B: Biological Sciences
سال: 2009
ISSN: 0962-8436,1471-2970
DOI: 10.1098/rstb.2009.0085